Identification of 2-fluoro-8-methyl-11-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5H-dibenzo[b,e][1,4]diazepine with clozapine-like mixed activities at muscarinic acetylcholine, dopamine, and serotonin receptors

MeSH terms

• Acetylcholine / chemistry
• Animals
• Antipsychotic Agents / administration & dosage
• Antipsychotic Agents / chemistry*
• Antipsychotic Agents / pharmacokinetics
• Azepines / administration & dosage
• Azepines / chemical synthesis*
• Azepines / pharmacokinetics
• Cholinergic Agents / chemistry
• Clozapine / administration & dosage
• Clozapine / chemistry*
• Clozapine / pharmacokinetics
• Dopamine / chemistry
• Drug Evaluation, Preclinical
• Humans
• Mice
• Olanzapine / chemistry
• Protein Binding
• Quetiapine Fumarate / chemistry
• Receptors, Cholinergic / chemistry*
• Receptors, Cholinergic / metabolism
• Receptors, Dopamine / chemistry*
• Receptors, Dopamine / metabolism
• Receptors, Serotonin / chemistry*
• Receptors, Serotonin / metabolism
• Small Molecule Libraries / chemistry
• Small Molecule Libraries / pharmacology
• Structure-Activity Relationship